Fresno County, officially the County of Fresno, is a county located in the central portion of the U.S. state of California. As of the 2020 Census, the population was 1,008,654. The county seat is Fresno, the fifth-most populous city in California. Fresno County comprises the Fresno, CA Metropolitan Statistical Area, which is part of the Fresno–Madera, C…Fresno County, officially the County of Fresno, is a county located in the central portion of the U.S. state of California. As of the 2020 Census, the population was 1,008,654. The county seat is Fresno, the fifth-most populous city in California. Fresno County comprises the Fresno, CA Metropolitan Statistical Area, which is part of the Fresno–Madera, CA Combined Statistical Area. It is located in the Central Valley, south of Stockton and north of Bakersfield. Since 2010, statewide droughts in California have further strained both Fresno County's and the entire Central Valley's water security.