Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss will ...

The San Francisco 49ers entered Saturday's game with just four running backs, and they lost one of them in the third quarter.

Injuries have been running rampant on the San Francisco 49ers since training camp began. They can’t even continue their kicker competition or have three quarter ...

Discover the top breakout running backs for 2025 fantasy football drafts, including Jordan Mason, Isaac Guerendo, and Omarion ...

The 49ers scored a touchdown on their opening series of the preseason, then their defense crumbled in a 30-9 loss against the ...

Injuries forced running back Isaac Guerendo and fullback Kyle Juszczyk out of Saturday’s practice at 49ers training camp.

Stats and projections for Isaac Guerendo in fantasy football, including ADP, insights, and 2025 outlook, as the San Francisco ...

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

The San Francisco 49ers added some running back depth to their roster ahead of their preseason opener vs. the Denver Broncos.

Last year, the San Francisco 49ers saw their skill-position corps decimated by injuries. Star running back Christian ...

Isaac Guerendo ’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids had a big race. Isaac was 5 or 6 at the time.