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Gut3d
Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor
Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...
Gut3d
Small intestinal contrast ultrasound versus imaging and enteroscopy in Crohn’s disease
In patients with small intestinal Crohn’s disease (CD), there is a need for a simple, non-invasive test to reduce dependence on invasive procedures (eg, enteroscopy) and costly imaging (eg, MRI or CT ...
Gut3d
Adenoma detection and subsequent colorectal cancer risk: is the race really over?
A high adenoma detection rate (ADR) is vital for effective colorectal cancer (CRC) screening, but evidence suggests limited additional benefit beyond a certain threshold. In a pooled analysis of five ...
Gut9d
Non-invasive risk-based surveillance of hepatocellular carcinoma in patients with metabolic dysfunction-associated steatotic liver disease
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of the general population and is ...
Gut4d
Extracellular vesicle-induced lipid dysregulation drives liver premetastatic niche formation in colorectal cancer
Background Liver metastasis is a major cause of mortality in patients with colorectal cancer (CRC). Understanding how CRC cells influence the formation of hepatic premetastatic niches (PMNs) is ...
gut.bmj1d
P270 Prevalence and impact of neurodiversity in patients with hypermobility spectrum disorders attending a neurogastroenterology clinic - Gut
Introduction Neurodiversity (ND) encompasses diagnoses of attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD), dyslexia and dyspraxia. Studies describe overlap of clinical ...
gut.bmj1d
P45 The impact of a new nurse-led community NAFLD clinic on patient care | Gut
Methods Short-term external funding was secured for a pilot to assess patients from primary care with suspected NAFLD and indeterminate Fib4 test in a dedicated Band 7 specialist nurse-led clinic, ...
gut.bmj14d
ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation | Gut
Objective Extracellular matrix protein 1 (ECM1) serves as a gatekeeper of hepatic fibrosis by maintaining transforming growth factor-β1 (TGF-β1) in its latent form. ECM1 knockout (KO) causes latent (L ...
gut.bmj9d
Enhancing non-invasive early detection of gastric cancer: a critical reflection on exosome ncRNA and machine learning | Gut
We have carefully reviewed the article titled ‘Construction of exosome non-coding RNA feature for non-invasive, early detection of gastric cancer patients by machine learning: a multi-cohort study’ by ...
gut.bmj12d
Retraction: Unleashing the potential of exosome ncRNAs for early gastric cancer detection—a critical appraisal of machine learning approaches | Gut
Zeng X. Unleashing the potential of exosome ncRNAs for early gastric cancer detection—a critical appraisal of machine learning approaches. Gut 2025;74:1191–1192.
gut.bmj1d
Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro - Gut
Objective Exhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection are broadly heterogeneous. Characterisation of their functional impairment may allow to distinguish patients ...