Systemic Light Chain Amyloidosis | New England Journal of Medicine
Jun 26, 2024 · Fibrillogenesis in immunoglobulin light chain (AL) amyloidosis is initiated from a small B-cell clone in the bone marrow that produces thermodynamically and kinetically unstable immunoglobulin ...
New England Journal of Medicine
The New England Journal of Medicine is a leading medical journal providing research, reviews, and commentary on clinical practice and biomedical science.
Rheumatoid Arthritis — Common Origins, Divergent Mechanisms
Feb 8, 2023 · Rheumatoid arthritis is a chronic, systemic autoimmune disease manifested primarily as inflammatory arthritis, typically involving the small joints of the hands and feet. It can lead to severe disa...
Management of Insomnia | New England Journal of Medicine
Jul 17, 2024 · Insomnia is common and frequently occurs with other disorders. First-line cognitive behavioral therapy with or without medication can produce rapid, sustained alleviation of insomnia symptoms.
Climate Change, Extreme Heat, and Health | NEJM
May 15, 2024 · The frequency, duration, and intensity of heat waves in the United States have increased in recent decades ().The annual number of heat waves is now twice that in the 1980s, and the heat wave ...
Fundamentals of Medical Ethics | NEJM
Dec 16, 2023 · The editors announce a new Perspective series exploring key ethical questions facing medicine today; the hope is that medical ethics can keep pace with the evolution — and revolutions — in ...
Long Covid Defined | New England Journal of Medicine
Jul 31, 2024 · Members of the National Academies of Sciences, Engineering, and Medicine describe the process and rationale for the development of the 2024 definition of persistent Covid-19 symptoms (long Covid).
Effect of Early Treatment with Ivermectin among Patients with …
Mar 30, 2022 · One drug that has received considerable public use and interest is ivermectin, which is typically used as an antiparasitic drug. Ivermectin inhibits the chloride channels of helminthic parasites ...
Biologic Therapies for Severe Asthma | New England Journal of …
Jan 12, 2022 · Patients with severe asthma are at increased risk for a decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may be required to reduce the disease burden.
Tirzepatide versus Semaglutide Once Weekly in Patients with Type …
Jun 25, 2021 · Tirzepatide is a dual glucose-dependent insulinotropic polypeptide–GLP-1 receptor agonist. Its structure is primarily based on the glucose-dependent insulinotropic polypeptide amino acid ...